Kallikrein-related Peptidase 5 Functions in Proteolytic Processing of Profilaggrin in Cultured Human Keratinocytes

Filaggrin protein is synthesized in the stratum granulosum of the skin and contributes to the formation of the human skin barrier. Profilaggrin is cleaved by proteolytic enzymes and converted to functional filaggrin, but its processing mechanism remains not fully elucidated. Kallikrein-related pepti...

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Main Authors: Sakabe, Jun-ichi, Yamamoto, Mami, Hirakawa, Satoshi, Motoyama, Akira, Ohta, Isao, Tatsuno, Kazuki, Ito, Taisuke, Kabashima, Kenji, Hibino, Toshihiko, Tokura, Yoshiki
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Protein Synthesis and Degradation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682523/
https://ncbi.nlm.nih.gov/pubmed/23629652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476820
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