Bleomycin Hydrolase Is Regulated Biphasically in a Differentiation- and Cytokine-dependent Manner: RELEVANCE TO ATOPIC DERMATITIS

Loss-of-function mutation in the profilaggrin gene is a major risk factor for atopic dermatitis (AD). Previously, we showed that a neutral cysteine protease, bleomycin hydrolase (BH), has a role in generating natural moisturizing factors, and calpain I is an upstream protease in the filaggrin degrad...

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Bibliographic Details
Main Authors: Kamata, Yayoi, Yamamoto, Mami, Kawakami, Fumitaka, Tsuboi, Ryoji, Takeda, Atsushi, Ishihara, Kazuhiko, Hibino, Toshihiko
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048707/
https://ncbi.nlm.nih.gov/pubmed/21190945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169292
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