Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2(+) glial cells

Interleukin 17(IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κ B activator 1(Act1), the key transducer of IL-17R signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes, astrocytes)results in attenuated severity of experimental autoim...

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Hoofdauteurs: Kang, Zizhen, Wang, Chenhui, Zepp, Jarod, Wu, Ling, Sun, Kevin, Zhao, Junjie, Chandrasekharan, Unni, DiCorleto, Paul E., Trapp, Bruce D., Ransohoff, Richard M., Li, Xiaoxia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106025/
https://ncbi.nlm.nih.gov/pubmed/23995070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3505
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