IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

Cuprizone inhibits mitochondrial function and induces demyelination in the corpus callosum, which resembles pattern III lesions in multiple sclerosis patients. However, the molecular and cellular mechanism by which cuprizone induces demyelination remains unclear. Interleukin-17 (IL-17) secreted by T...

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Bibliografiske detaljer
Main Authors: Kang, Zizhen, Liu, Liping, Spangler, Roo, Spear, Charles, Wang, Chenhui, Gulen, Muhammet Fatih, Veenstra, Mike, Ouyang, Wenjun, Ransohoff, Richard M., Li, Xiaoxia
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412399/
https://ncbi.nlm.nih.gov/pubmed/22699909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0841-12.2012
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