IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

Cuprizone inhibits mitochondrial function and induces demyelination in the corpus callosum, which resembles pattern III lesions in multiple sclerosis patients. However, the molecular and cellular mechanism by which cuprizone induces demyelination remains unclear. Interleukin-17 (IL-17) secreted by T...

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Main Authors: Kang, Zizhen, Liu, Liping, Spangler, Roo, Spear, Charles, Wang, Chenhui, Gulen, Muhammet Fatih, Veenstra, Mike, Ouyang, Wenjun, Ransohoff, Richard M., Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412399/
https://ncbi.nlm.nih.gov/pubmed/22699909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0841-12.2012
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