A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

BACKGROUND AND PURPOSE: The human CCR5 receptor is a co-receptor for HIV-1 infection and a target for anti-viral therapy. A greater understanding of the binding kinetics of small molecule allosteric ligand interactions with CCR5 will lead to a better understanding of the binding process and may help...

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Détails bibliographiques
Auteurs principaux: Swinney, David C, Beavis, Paul, Chuang, Kai-Ting, Zheng, Yue, Lee, Ina, Gee, Peter, Deval, Jerome, Rotstein, David M, Dioszegi, Marianna, Ravendran, Palani, Zhang, Jun, Sankuratri, Surya, Kondru, Rama, Vauquelin, Georges
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2014
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105926/
https://ncbi.nlm.nih.gov/pubmed/24628038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12683
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