Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.

CD28 is a costimulatory receptor found on the surface of most T lymphocytes. Engagement of CD28 induces interleukin 2 (IL-2) production and cell proliferation when combined with an additional signal such as treatment with phorbol ester, an activator of protein kinase C. Recent studies have establish...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hutchcroft, J E, Franklin, D P, Tsai, B, Harrison-Findik, D, Varticovski, L, Bierer, B E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8808
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