Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

BACKGROUND: The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In this regard, we have demonstrated that claudin-1 expression in colon cancer cells potenti...

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Detalhes bibliográficos
Main Authors: Pope, Jillian L, Ahmad, Rizwan, Bhat, Ajaz A, Washington, Mary K, Singh, Amar B, Dhawan, Punita
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105545/
https://ncbi.nlm.nih.gov/pubmed/24997475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-167
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