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Claudin-1 Regulates Intestinal Epithelial Homeostasis through the Modulation of Notch Signaling

OBJECTIVE: Claudin-1 expression is increased and dysregulated in colorectal cancer and causally associates with the dedifferentiation of colonic epithelial cells, cancer progression and metastasis. Here, we have sought to determine the role claudin-1 plays in the regulation of intestinal epithelial...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pope, Jillian L., Bhat, Ajaz. A., Sharma, Ashok, Ahmad, Rizwan, Krishnan, Moorthy, Washington, Mary K., Beauchamp, Robert D., Singh, Amar B., Dhawan, Punita
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083824/
https://ncbi.nlm.nih.gov/pubmed/23766441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-304241
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