Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

BACKGROUND: The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lu, Lei, Xu, Xiaobing, Zhang, Bin, Zhang, Rongsheng, Ji, Hongzan, Wang, Xuan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104995/
https://ncbi.nlm.nih.gov/pubmed/24502656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-36
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky