Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

BACKGROUND: The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated...

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Bibliografiske detaljer
Main Authors: Lu, Lei, Xu, Xiaobing, Zhang, Bin, Zhang, Rongsheng, Ji, Hongzan, Wang, Xuan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104995/
https://ncbi.nlm.nih.gov/pubmed/24502656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-36
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