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Site-specific AGE modifications in the ECM: a role for glyoxal in protein damage in diabetes
Non-enzymatic modification of proteins in hyperglycemia is a major proposed mechanism of diabetic complications. Specifically, advanced glycation end products (AGEs) derived from hyperglycemia-induced reactive carbonyl species (RCS) can have pathogenic consequences when they target functionally crit...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104777/ https://ncbi.nlm.nih.gov/pubmed/23492568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/cclm-2012-0818 |
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