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A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

Chaperones are abundant cellular proteins that promote the folding and function of their substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set of co-factors (co-chaperones) that regulate their specificity and function. However, how these co-chaperones regulate...

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Detalhes bibliográficos
Main Authors: Taipale, Mikko, Tucker, George, Peng, Jian, Krykbaeva, Irina, Lin, Zhen-Yuan, Larsen, Brett, Choi, Hyungwon, Berger, Bonnie, Gingras, Anne-Claude, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104544/
https://ncbi.nlm.nih.gov/pubmed/25036637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.039
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