O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of HIF-1 pathway

The Hexosamine Biosynthetic Pathway leads to elevated post-translation addition of O-linked-βN-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-GlcNAcase (OGA) levels. Reducing O-GlcNAcylat...

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Hlavní autoři: Ferrer, Christina M., Lynch, Thomas P., Sodi, Valerie L., Falcone, John N., Schwab, Luciana P., Peacock, Danielle L., Vocadlo, David J., Seagroves, Tiffany N., Reginato, Mauricio J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104413/
https://ncbi.nlm.nih.gov/pubmed/24857547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.026
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