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O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of HIF-1 pathway
The Hexosamine Biosynthetic Pathway leads to elevated post-translation addition of O-linked-βN-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-GlcNAcase (OGA) levels. Reducing O-GlcNAcylat...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104413/ https://ncbi.nlm.nih.gov/pubmed/24857547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.026 |
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