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Interferon Lambda Alleles Predict Innate Antiviral Immune Responses and Hepatitis C Virus Permissiveness

Hepatitis C virus (HCV) infection can result in viral chronicity or clearance. Although host genetics and particularly genetic variation in the interferon lambda (IFNL) locus are associated with spontaneous HCV clearance and treatment success, the mechanisms guiding these clinical outcomes remain un...

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Detalhes bibliográficos
Main Authors: Sheahan, Timothy, Imanaka, Naoko, Marukian, Svetlana, Dorner, Marcus, Liu, Peng, Ploss, Alexander, Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104123/
https://ncbi.nlm.nih.gov/pubmed/24528865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.007
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