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Design of a colicin E7 based chimeric zinc-finger nuclease
Colicin E7 is a natural bacterial toxin. Its nuclease domain (NColE7) enters the target cell and kills it by digesting the nucleic acids. The HNH-motif as the catalytic centre of NColE7 at the C-terminus requires the positively charged N-terminal loop for the nuclease activity—offering opportunities...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104000/ https://ncbi.nlm.nih.gov/pubmed/24952471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-014-9765-8 |
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