Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells

BACKGROUND: Elevated level of reactive carbonyl species, such as methylglyoxal, triggers carbonyl stress and activates a series of inflammatory responses leading to accelerated vascular damage. Edaravone is the active substance of a Japanese medicine, which aids neurological recovery following acute...

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Main Authors: Tóth, Andrea E., Walter, Fruzsina R., Bocsik, Alexandra, Sántha, Petra, Veszelka, Szilvia, Nagy, Lajos, Puskás, László G., Couraud, Pierre-Olivier, Takata, Fuyuko, Dohgu, Shinya, Kataoka, Yasufumi, Deli, Mária A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102474/
https://ncbi.nlm.nih.gov/pubmed/25033388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100152
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