Sweat Chloride as A Biomarker of CFTR Activity: Proof of Concept and Ivacaftor Clinical Trial Data

BACKGROUND: We examined data from a Phase 2 trial {NCT00457821 } of ivacaftor, a CFTR potentiator, in cystic fibrosis (CF) patients with a G551D mutation to evaluate standardized approaches to sweat chloride measurement and to explore the use of sweat chloride and nasal potential difference (NPD) to...

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Auteurs principaux: Accurso, Frank J., Van Goor, Fredrick, Zha, Jiuhong, Stone, Anne J., Dong, Qunming, Ordonez, Claudia L., Rowe, Steven M., Clancy, John Paul, Konstan, Michael W., Hoch, Heather E., Heltshe, Sonya L., Ramsey, Bonnie W., Campbell, Preston W., Ashlock, Melissa A.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102431/
https://ncbi.nlm.nih.gov/pubmed/24660233
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