H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice

We examined the effects of two over-the-counter H1-antihistamines on the progression of fatty liver disease in male C57Bl/6 wild-type and apolipoprotein E (ApoE)−/− mice. Mice were fed a high-fat diet (HFD) for 3 mo, together with administration of either cetirizine (4 mg/kg body wt) or fexofenadine...

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Detalhes bibliográficos
Main Authors: Raveendran, Vineesh V., Kassel, Karen M., Smith, Donald D., Luyendyk, James P., Williams, Kurt J., Cherian, Rachel, Reed, Gregory A., Flynn, Colleen A., Csanaky, Iván L., Lickteig, Andrew L., Pratt-Hyatt, Matthew J., Klaassen, Curtis D., Dileepan, Kottarappat N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101675/
https://ncbi.nlm.nih.gov/pubmed/24852568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00027.2014
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