O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41

Dysfunctions in Wnt signaling increase β-catenin stability and are associated with cancers, including colorectal cancer. In addition, β-catenin degradation is decreased by nutrient-dependent O-GlcNAcylation. Human colon tumors and colons from mice fed high-carbohydrate diets exhibited higher amounts...

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Detalhes bibliográficos
Main Authors: Olivier-Van Stichelen, Stéphanie, Dehennaut, Vanessa, Buzy, Armelle, Zachayus, Jean-Luc, Guinez, Céline, Mir, Anne-Marie, El Yazidi-Belkoura, Ikram, Copin, Marie-Christine, Boureme, Didier, Loyaux, Denis, Ferrara, Pascual, Lefebvre, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101651/
https://ncbi.nlm.nih.gov/pubmed/24744147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-243535
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