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O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41
Dysfunctions in Wnt signaling increase β-catenin stability and are associated with cancers, including colorectal cancer. In addition, β-catenin degradation is decreased by nutrient-dependent O-GlcNAcylation. Human colon tumors and colons from mice fed high-carbohydrate diets exhibited higher amounts...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101651/ https://ncbi.nlm.nih.gov/pubmed/24744147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-243535 |
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