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Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons

Recent studies have demonstrated that human tau can be secreted by neurons and non-neuronal cells, an event linked to the propagation of tau pathology in the brain. In the present study, we confirmed that under physiological conditions, one tau-positive band was detected in the culture medium with a...

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Autors principals: Mohamed, Nguyen-Vi, Plouffe, Vanessa, Rémillard-Labrosse, Gaudeline, Planel, Emmanuel, Leclerc, Nicole
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101526/
https://ncbi.nlm.nih.gov/pubmed/25030297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05715
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