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Decoding F508del Misfolding in Cystic Fibrosis
The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. T...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101494/ https://ncbi.nlm.nih.gov/pubmed/24970227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom4020498 |
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