Hepatitis B Virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity

Nucleos(t)ide analog drugs profoundly suppress Hepatitis B Virus (HBV) replication but rarely cure the infection, so therapy is usually life-long. The nucleos(t)ide analogs inhibit the viral DNA polymerase and often push HBV to the brink of extinction, so it may be possible to eradicate HBV by suppr...

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Huvudupphovsmän: Cai, Catherine W., Lomonosova, Elena, Moran, Eileen A., Cheng, Xiaohong, Patel, Kunjan B., Bailly, Fabrice, Cotelle, Philipe, Meyers, Marvin J., Tavis, John E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101055/
https://ncbi.nlm.nih.gov/pubmed/24858512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.05.007
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