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A Computational Model Predicts that Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels
The atrial G protein-regulated inwardly rectifying K(+) (GIRK1 and GIRK4) heterotetrameric channels underlie the acetylcholine-induced K(+) current responsible for vagal inhibition of heart rate and are activated by the G protein βγ subunits (Gβγ). We used a multistage protein-protein docking approa...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4100999/ https://ncbi.nlm.nih.gov/pubmed/23943609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004075 |
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