A Computational Model Predicts that Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels

The atrial G protein-regulated inwardly rectifying K(+) (GIRK1 and GIRK4) heterotetrameric channels underlie the acetylcholine-induced K(+) current responsible for vagal inhibition of heart rate and are activated by the G protein βγ subunits (Gβγ). We used a multistage protein-protein docking approa...

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Bibliographic Details
Main Authors: Mahajan, Rahul, Ha, Junghoon, Zhang, Miao, Kawano, Takeharu, Kozasa, Tohru, Logothetis, Diomedes E.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100999/
https://ncbi.nlm.nih.gov/pubmed/23943609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004075
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