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SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells

Limited treatment options are available for chronic myelogenous leukemia (CML) patients who develop imatinib mesylate (IM) resistance. Here we proposed a novel combination regimen, a co-administration of S116836, a novel small molecule multi-targeted tyrosine kinase inhibitor that was synthesized by...

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Bibliografiska uppgifter
Huvudupphovsmän: Bu, Qiangui, Cui, Lijing, Li, Juan, Du, Xin, Zou, Waiyi, Ding, Ke, Pan, Jingxuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100996/
https://ncbi.nlm.nih.gov/pubmed/24759597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28931
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