Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells

The FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) fusion oncogene is the driver factor in a subset of patients with hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL). Most FIP1L1-PDGFRα-positive patients respond well to the tyrosine kinase inhibitor (TK...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Shen, Yingying, Ren, Xiaomei, Ding, Ke, Zhang, Zhang, Wang, Deping, Pan, Jingxuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279382/
https://ncbi.nlm.nih.gov/pubmed/25431951
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