Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin

BACKGROUND: T674I FIP1L1-PDGFRα in a subset of chronic eosinophilic leukemia (CEL) is a gatekeeper mutation that is resistant to many tyrosine kinase inhibitors (TKIs) (e.g., imatinib, nilotinib and dasatinib), similar to T315I Bcr-Abl. Therefore, novel TKIs effective against T674I FIP1L1-PDGFRα are...

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Bibliographic Details
Main Authors: Jin, Yanli, Ding, Ke, Li, Honglin, Xue, Mengzhu, Shi, Xiaoke, Wang, Chengyan, Pan, Jingxuan
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928078/
https://ncbi.nlm.nih.gov/pubmed/24472312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-17
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