Functional CYP2B6 variants and virologic response to an efavirenz-containing regimen in Port-au-Prince, Haiti

OBJECTIVES: Efavirenz is widely prescribed for HIV-1 infection. Three polymorphisms in CYP2B6 define plasma efavirenz trough concentration strata that vary across an ∼10-fold range. We characterized associations between human genetic polymorphisms and virologic response among participants who receiv...

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Main Authors: Haas, David W., Severe, Patrice, Jean Juste, Marc Antoine, Pape, Jean William, Fitzgerald, Daniel W.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100704/
https://ncbi.nlm.nih.gov/pubmed/24695352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku088
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