Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing’s syndrome

CONTEXT: Primary pigmented nodular adrenocortical disease (PPNAD) can lead to steroid hormone overproduction. Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop....

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Autori principali: Hofland, Johannes, de Herder, Wouter W, Derks, Lieke, Hofland, Leo J, van Koetsveld, Peter M, de Krijger, Ronald R, van Nederveen, Francien H, Horvath, Anelia, Stratakis, Constantine A, de Jong, Frank H, Feelders, Richard A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100689/
https://ncbi.nlm.nih.gov/pubmed/23065993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-12-0594
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