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Allele-specific Silencing of Mutant Myh6 Allele in Mice Suppresses Hypertrophic Cardiomyopathy
Dominant mutations in sarcomere proteins such as the myosin heavy chains (MHC) are the leading genetic causes of human hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Here we demonstrate that expression of the HCM cardiac MHC gene (Myh6) R403Q mutation in mice can be selectively...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4100553/ https://ncbi.nlm.nih.gov/pubmed/24092743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236921 |
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