Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner

PURPOSE: Brain metastases of breast cancer cause neurocognitive damage and are incurable. We evaluated a role for temozolomide in the prevention of brain metastases of breast cancer in experimental brain metastasis models. EXPERIMENTAL DESIGN: Temozolomide was administered in mice following earlier...

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Main Authors: Palmieri, Diane, Duchnowska, Renata, Woditschka, Stephan, Hua, Emily, Qian, Yongzhen, Biernat, Wojciech, Sosińska-Mielcarek, Katarzyna, Gril, Brunilde, Stark, Andreas, Hewitt, Stephen, Liewehr, David J, Steinberg, Seth M, Jassem, Jacek, Steeg, Patricia S
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100541/
https://ncbi.nlm.nih.gov/pubmed/24634373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2588
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