Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis

PURPOSE: Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved anti-angiogenic drug that targets VEGFR1-3, PDGFRβ, PDGFRα and c-kit, for prevention of experimental brain metastases and mechanism of action. EXPERIM...

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Hlavní autoři: Gril, Brunilde, Palmieri, Diane, Qian, Yong, Smart, DeeDee, Ileva, Lilia, Liewehr, David J., Steinberg, Seth M., Steeg, Patricia S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059742/
https://ncbi.nlm.nih.gov/pubmed/21081656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1603
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