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Propensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins
Protein aggregation, linked to many of diseases, is initiated when monomers access rogue conformations that are poised to form amyloid fibrils. We show, using simulations of src SH3 domain, that mechanical force enhances the population of the aggregation prone (N*) states, which are rarely populated...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4100209/ https://ncbi.nlm.nih.gov/pubmed/24846645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.05.007 |
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