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Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires

Amyloid-like fibrils from a number of small peptides that are unrelated by sequence adopt a cross-β-spine in which the two sheets fully interdigitate to create a dry interface. Formation of such a dry interface is usually associated with self-assembly of extended hydrophobic surfaces. Here we invest...

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Autors principals: Reddy, Govardhan, Straub, John E., Thirumalai, D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003024/
https://ncbi.nlm.nih.gov/pubmed/21098298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008616107
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