Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease()

Progressive loss of substantia nigra dopamine neurons (SN DA) is a hallmark of aging and of Parkinson's disease (PD). Mutations in PARK genes cause familial PD forms. Increased expression of alpha-synuclein (PARK4) is a disease-triggering event in familial PD and also observed in SN DA neurons...

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Autors principals: Schlaudraff, Falk, Gründemann, Jan, Fauler, Michael, Dragicevic, Elena, Hardy, John, Liss, Birgit
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099518/
https://ncbi.nlm.nih.gov/pubmed/24742361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.03.016
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