Detecting Novel Genetic Variants Associated with Isoniazid-Resistant Mycobacterium tuberculosis

BACKGROUND: Isoniazid (INH) is a highly effective antibiotic central for the treatment of Mycobacterium tuberculosis (MTB). INH-resistant MTB clinical isolates are frequently mutated in the katG gene and the inhA promoter region, but 10 to 37% of INH-resistant clinical isolates have no detectable al...

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Main Authors: Shekar, Sandhya, Yeo, Zhen Xuan, Wong, Joshua C. L., Chan, Maurice K. L., Ong, Danny C. T., Tongyoo, Pumipat, Wong, Sin-Yew, Lee, Ann S. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099304/
https://ncbi.nlm.nih.gov/pubmed/25025225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102383
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