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Inactivating UBE2M Impacts the DNA Damage Response and Genome Integrity Involving Multiple Cullin Ligases

Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA br...

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書目詳細資料
Main Authors: Cukras, Scott, Morffy, Nicholas, Ohn, Takbum, Kee, Younghoon
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099125/
https://ncbi.nlm.nih.gov/pubmed/25025768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101844
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