Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

Base modifications of cytosine are an important aspect of chromatin biology, as they can directly regulate gene expression, while DNA repair ensures that those modifications retain genome integrity. Here we characterize how cytosine DNA deaminase AID can initiate DNA demethylation. In vitro, AID ini...

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Main Authors: Franchini, Don-Marc, Chan, Chun-Fung, Morgan, Hugh, Incorvaia, Elisabetta, Rangam, Gopinath, Dean, Wendy, Santos, Fatima, Reik, Wolf, Petersen-Mahrt, Svend K.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098905/
https://ncbi.nlm.nih.gov/pubmed/25025377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097754
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