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Simultaneous In Vitro Characterisation of DNA Deaminase Function and Associated DNA Repair Pathways
During immunoglobulin (Ig) diversification, activation-induced deaminase (AID) initiates somatic hypermutation and class switch recombination by catalysing the conversion of cytosine to uracil. The synergy between AID and DNA repair pathways is fundamental for the introduction of mutations, however...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857227/ https://ncbi.nlm.nih.gov/pubmed/24349193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082097 |
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