A transgenic rabbit model for human hypertrophic cardiomyopathy

Certain mutations in genes for sarcomeric proteins cause hypertrophic cardiomyopathy (HCM). We have developed a transgenic rabbit model for HCM caused by a common point mutation in the β-myosin heavy chain (MyHC) gene, R400Q. Wild-type and mutant human β-MyHC cDNAs were cloned 3′ to a 7-kb murine β-...

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Autors principals: Marian, Ali J., Wu, Yun, Lim, Do-Sun, McCluggage, Meghan, Youker, Keith, Yu, Qun-tao, Brugada, Ramon, DeMayo, Francesco, Quinones, Miguel, Roberts, Robert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1999
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC409884/
https://ncbi.nlm.nih.gov/pubmed/10606622
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