Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function

PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here we show that PTEN homo-dimerizes, and in this active conformation exerts lipid phosphatase activity on PtdIns(3,4,5)P(3). We demonstrate that catalytically inactive cancer-associated PTEN mutants heter...

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Hlavní autoři: Papa, Antonella, Wan, Lixin, Bonora, Massimo, Salmena, Leonardo, Song, Min Sup, Hobbs, Robin M., Lunardi, Andrea, Webster, Kaitlyn, Ng, Christopher, Newton, Ryan H., Knoblauch, Nicholas, Guarnerio, Jlenia, Ito, Keisuke, Turka, Laurence A., Beck, Andy H., Pinton, Paolo, Bronson, Roderick, Wei, Wenyi, Pandolfi, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098792/
https://ncbi.nlm.nih.gov/pubmed/24766807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.027
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