Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function

PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here we show that PTEN homo-dimerizes, and in this active conformation exerts lipid phosphatase activity on PtdIns(3,4,5)P(3). We demonstrate that catalytically inactive cancer-associated PTEN mutants heter...

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Detalhes bibliográficos
Main Authors: Papa, Antonella, Wan, Lixin, Bonora, Massimo, Salmena, Leonardo, Song, Min Sup, Hobbs, Robin M., Lunardi, Andrea, Webster, Kaitlyn, Ng, Christopher, Newton, Ryan H., Knoblauch, Nicholas, Guarnerio, Jlenia, Ito, Keisuke, Turka, Laurence A., Beck, Andy H., Pinton, Paolo, Bronson, Roderick, Wei, Wenyi, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098792/
https://ncbi.nlm.nih.gov/pubmed/24766807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.027
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