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TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

Systemic lupus erythematosus is characterized by the production of autoantibodies against nucleic acid-associated Ags. We previously found that Tlr7 was required for anti-Sm and Tlr9 for anti-chromatin autoantibodies. Yet, although Tlr7 deficiency ameliorated disease, Tlr9 deficiency exacerbated it....

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Autors principals: Nickerson, Kevin M., Christensen, Sean R., Shupe, Jonathan, Kashgarian, Michael, Kim, Daniel, Elkon, Keith, Shlomchik, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098568/
https://ncbi.nlm.nih.gov/pubmed/20089701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902592
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