Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice

To elucidate the role of cardiac myosin-binding protein-C (MyBP-C) in myocardial structure and function, we have produced mice expressing altered forms of this sarcomere protein. The engineered mutations encode truncated forms of MyBP-C in which the cardiac myosin heavy chain-binding and titin-bindi...

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Pubblicato in:J Clin Invest
Autori principali: McConnell, Bradley K., Jones, Karen A., Fatkin, Diane, Arroyo, Luis H., Lee, Richard T., Aristizabal, Orlando, Turnbull, Daniel H., Georgakopoulos, Dimitrios, Kass, David, Bond, Meredith, Niimura, Hideshi, Schoen, Frederick J., Conner, David, Fischman, Donald H., Seidman, Christine E., Seidman, J.G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1999
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409819/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10545522/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7377
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