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2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel
Water is an integral part of the homotetrameric M2 proton channel of the influenza A virus, which not only assists proton conduction but could also play an important role in stabilizing channel-blocking drugs. Herein, we employ two dimensional infrared (2D IR) spectroscopy and site-specific IR probe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Institute of Physics
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4098053/ https://ncbi.nlm.nih.gov/pubmed/24952572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4881188 |
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