Serine Protease Inhibition Attenuates rIL-12-Induced GZMA Activity and Proinflammatory Events by Modulating the Th2 Profile From Estrogen-Treated Mice

Estrogen has potent immunomodulatory effects on proinflammatory responses, which can be mediated by serine proteases. We now demonstrate that estrogen increased the extracellular expression and IL-12-induced activity of a critical member of serine protease family Granzyme A, which has been shown to...

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Detalhes bibliográficos
Main Authors: Karpuzoglu, Ebru, Schmiedt, Chad W., Pardo, Julian, Hansen, Megan, Guo, Tai L., Holladay, Steven D., Gogal, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Growth Factors-Cytokines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097994/
https://ncbi.nlm.nih.gov/pubmed/24840346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1045
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