Signal Transducer and Activation of Transcription (STAT) 4β, a Shorter Isoform of Interleukin-12-Induced STAT4, Is Preferentially Activated by Estrogen

Estrogen, a natural immunomodulatory compound, has been shown to promote the induction of a prototype T helper 1 cytokine, interferon (IFN)-γ, as well as to up-regulate IFNγ-mediated proinflammatory molecules (nitric oxide, cyclooxygenase 2, monocyte chemoattractant protein 1). Because IL-12 is a ma...

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Hauptverfasser: Karpuzoglu, Ebru, Phillips, Rebecca A., Dai, Rujuan, Graniello, Carmine, Gogal, Robert M., Ahmed, S. Ansar
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654738/
https://ncbi.nlm.nih.gov/pubmed/18988675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0832
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