Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Group on Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity

(E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP). Although missing a DNA-binding domai...

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Main Authors: Dawson, Marcia I., Xia, Zebin, Jiang, Tao, Ye, Mao, Fontana, Joseph A., Farhana, Lulu, Patel, Bhaumik, Xue, Li Ping, Bhuiyan, Mohammad, Pellicciari, Roberto, Macchiarulo, Antonio, Nuti, Roberto, Zhang, Xiao-Kun, Han, Young-Hoon, Tautz, Lutz, Hobbs, Peter D., Jong, Ling, Waleh, Nahid, Chao, Wan-ru, Feng, Gen-Sheng, Pang, Yuhong, Su, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097887/
https://ncbi.nlm.nih.gov/pubmed/18759424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800456k
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