Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways

Pancreatic carcinoma has a dismal prognosis as it often presents as locally advanced or metastatic. We have found that exposure to adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 resulted in growth inhibition and apoptosis induction in PANC-1, Capan-2, and MiaPaCa-2 pancrea...

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Detalhes bibliográficos
Main Authors: Farhana, Lulu, Dawson, Marcia I., Das, Jayanta K., Murshed, Farhan, Xia, Zebin, Hadden, Timothy J., Hatfield, James, Fontana, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335256/
https://ncbi.nlm.nih.gov/pubmed/22570653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/796729
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